Article
The carboxypeptidase E knockout mouse exhibits endocrinological and behavioral deficits.
Endocrinology - 1 Dec 2004
Cawley Niamh X, Zhou Jiechun, Hill Joanna M, Abebe Daniel, Romboz Sylvie, Yanik Tulin, Rodriguiz Ramona M, Wetsel William C, Loh Y Peng
Abstract excerpt
A carboxypeptidase E (CPE) knockout (KO) mouse was generated by deletion of exons 4 and 5 from the CPE gene, and its phenotype was characterized. KO mice became obese by 10-12 wk of age and reached 60-80 g by 40 wk. At this age, body fat content was more than double that in the wild-type (WT) controls. The null animals consumed more food overall, were less physically active during the light phase of the...
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