Article
Prohormone convertase 7 is necessary for the normal processing of cholecystokinin in mouse brain.
Biochemical and biophysical research communications - 22 Jan 2017
Anyetei-Anum Emmanuel N, Blum Alissa, Seidah Nabil G, Beinfeld Margery C
Abstract excerpt
Endoproteases in the secretory pathway process pro-cholecystokinin (CCK) into the biologically active forms found in the tissues that express CCK mRNA. Thus far, the endoproteases involved in CCK processing include cathepsin L and the prohormone convertases (PC) 1, 2, and 5. This study finds that PC7 is also critical for normal production of CCK in specific areas of the brain. Loss of PC7 results in decreased...
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