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Article

Spi-1 transgenic mice develop a clonal erythroleukemia which does not depend on p53 mutation.

Oncogene - 11 Jun 1998

Barnache S, Wendling F, Lacombe C, Denis N, Titeux M, Vainchenker W, Moreau-Gachelin F

Abstract excerpt

Spi-1 transcriptional activation and wild-type p53 extinction are two oncogenic alterations involved in the malignant transformation of erythroblasts during the Friend acute erythroleukemia. To dissect the contribution of these alterations in the deregulation of the differentiation and proliferation of erythroblasts, we generated spi-1 transgenic mice. Analysis of these animals revealed that Spi-1 overexpression...

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Identifiers

PMID: 9662331
DOI: 10.1038/sj.onc.1202095

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Spi-1 transgenic mice develop a clonal erythroleukemia which does not depend on p53 mutation.PMID 9662331Read ↗

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