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Article

Spi-1/PU.1 Transgenic Mice Develop Multistep Erythroleukemias

1 May 1996

Abstract excerpt

Insertional mutagenesis of the spi-1 gene is associated with the emergence of malignant proerythroblasts during Friend virus-induced acute erythroleukemia. To determine the role of spi-1/PU.1 in the genesis of leukemia, we generated spi-1 transgenic mice. In one founder line the transgene was overexpressed as an unexpected-size transcript in various mouse tissues. Homozygous transgenic animals gave rise to...

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Identifiers

PMID: 8628313
DOI: 10.1128/mcb.16.5.2453

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Research trail→

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Spi-1/PU.1 Transgenic Mice Develop Multistep ErythroleukemiasPMID 8628313Read ↗

Spi-1 transgenic mice develop a clonal erythroleukemia which does not depend on p53 mutation.Semantic proximity Read ↗

Kit-activating mutations cooperate with Spi-1/PU.1 overexpression to promote tumorigenic progression during erythroleukemia in mice.Semantic proximity Read ↗

Senescence is a Spi1-induced anti-proliferative mechanism in primary hematopoietic cells.Semantic proximity Read ↗

Spi-1/PU.1 oncoprotein affects splicing decisions in a promoter binding-dependent manner.Semantic proximity Read ↗

Spi-1 and Fli-1 directly activate common target genes involved in ribosome biogenesis in Friend erythroleukemic cells.Semantic proximity Read ↗

Unexpected and coordinated expression of Spi-1, Fli-1, and megakaryocytic genes in four Epo-dependent cell lines established from transgenic mice displaying erythroid-specific expression of a thermosensitive SV40 T antigen.Semantic proximity Read ↗

Spi-1/PU.1 Is a Positive Regulator of the Fli-1 Gene Involved in Inhibition of Erythroid Differentiation in Friend Erythroleukemic Cell LinesSemantic proximity Read ↗

Ezrin is a target for oncogenic Kit mutants in murine erythroleukemia.Semantic proximity Read ↗

Spi-1 and mutant p53 regulate different aspects of the proliferation and differentiation control of primary erythroid progenitors.Semantic proximity Read ↗

The Transcription Factor Spi-1/PU.1 Interacts with the Potential Splicing Factor TLSSemantic proximity Read ↗

Driver mutations in Janus kinases in a mouse model of B-cell leukemia induced by deletion of PU.1 and Spi-BSemantic proximity Read ↗

Endogenous p53 regulation and function in early stage Friend virus-induced tumor progression differs from that following DNA damage.Semantic proximity Read ↗

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