Article
Endogenous p53 regulation and function in early stage Friend virus-induced tumor progression differs from that following DNA damage.
Oncogene - 3 Sept 1998
Kelley L L, Hicks G G, Hsieh F F, Prasher J M, Green W F, Miller M D, Eide E J, Ruley H E
Abstract excerpt
Erythroleukemia induced by the anemia strain of Friend virus occurs in two stages. The first stage results in rapid expansion of pre-leukemic proerythroblasts (FVA cells) dependent on erythropoietin (Epo) for differentiation and survival in vitro. The second stage is characterized by emergence of...
Topics
- Animals
- Antibiotics, Antineoplastic
- Apoptosis
- Cell Differentiation
- Cell Division
- Cell Survival
- Cyclin-Dependent Kinase Inhibitor p21
- Cyclins
- DNA Damage
- Dactinomycin
- Disease Progression
- Erythroblasts
- Erythropoietin
- Female
- Friend murine leukemia virus