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Article

Senescence is a Spi1-induced anti-proliferative mechanism in primary hematopoietic cells.

Haematologica - 1 Nov 2017

Delestré Laure, Cui Hengxiang, Esposito Michela, Quiveron Cyril, Mylonas Elena, Penard-Lacronique Virginie, Bischof Oliver, Guillouf Christel

Abstract excerpt

Transcriptional deregulation caused by epigenetic or genetic alterations is a major cause of leukemic transformation. The Spi1/PU.1 transcription factor is a key regulator of many steps of hematopoiesis, and limits self-renewal of hematopoietic stem cells. The deregulation of its expression or activity contributes to leukemia, in which Spi1 can be either an oncogene or a tumor suppressor. Herein we explored...

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Identifiers

PMID: 28912174
DOI: 10.3324/haematol.2016.157636
PMCID: PMC5664389

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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