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Article

Ezrin is a target for oncogenic Kit mutants in murine erythroleukemia.

Blood - 15 Mar 2008

Monni Richard, Haddaoui Lamya, Naba Alexandra, Gallais Isabelle, Arpin Monique, Mayeux Patrick, Moreau-Gachelin Françoise

Abstract excerpt

The model of erythroleukemia caused by Spi-1/PU.1 transgenesis in mice is a multistage disease. A preleukemic step is characterized by an acute proliferation of proerythroblasts due to the arrest of differentiation provoked by Spi-1/PU.1. Later on, a blastic crisis occurs associated with somatic oncogenic mutations in the stem cell factor (SCF) receptor kit. To gain insights into the mechanisms of the leukemic...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 18182570
DOI: 10.1182/blood-2007-09-110510

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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