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Article

Spi-1/PU.1 oncoprotein affects splicing decisions in a promoter binding-dependent manner.

The Journal of biological chemistry - 14 Jul 2006

Guillouf Christel, Gallais Isabelle, Moreau-Gachelin Françoise

Abstract excerpt

The expression of the Spi-1/PU.1 transcription factor is tightly regulated as a function of the hematopoietic lineage. It is required for myeloid and B lymphoid differentiation. When overexpressed in mice, Spi-1 is associated with the emergence of transformed proerythroblasts unable to differentiate. In the course of a project undertaken to characterize the oncogenic function of Spi-1, we found that Spi-1...

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Identifiers

PMID: 16698794
DOI: 10.1074/jbc.M512049200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Spi-1/PU.1 oncoprotein affects splicing decisions in a promoter binding-dependent manner.PMID 16698794Read ↗

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