Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Spi-1 and Fli-1 directly activate common target genes involved in ribosome biogenesis in Friend erythroleukemic cells.

Molecular and cellular biology - 1 May 2009

Juban Gaëtan, Giraud Guillaume, Guyot Boris, Belin Stéphane, Diaz Jean-Jacques, Starck Joëlle, Guillouf Christel, Moreau-Gachelin Françoise, Morlé François

Abstract excerpt

Spi-1 and Fli-1 are ETS transcription factors recurrently deregulated in mouse erythroleukemia induced by Friend viruses. Since they share the same core DNA binding site, we investigated whether they may contribute to erythroleukemia by common mechanisms. Using inducible knockdown, we demonstrated that Fli-1 contributes to proliferation, survival, and differentiation arrest of erythroleukemic cells harboring an...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Friend murine leukemia virus
Share to Gene Knockdown Techniques

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Intercellular Signaling Peptides and Proteins

Share to Leukemia, Erythroblastic, Acute

Share to Peptides

Share to Proto-Oncogene Protein c-fli-1

Share to Ribosomes

Share to Tumor Cells, Cultured

Source

Open in PubMed Open full text

Identifiers

PMID: 19289502
DOI: 10.1128/MCB.01435-08
PMCID: PMC2682047

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Spi-1 and Fli-1 directly activate common target genes involved in ribosome biogenesis in Friend erythroleukemic cells.PMID 19289502Read ↗

Spi-1/PU.1 Is a Positive Regulator of the Fli-1 Gene Involved in Inhibition of Erythroid Differentiation in Friend Erythroleukemic Cell LinesSemantic proximity Read ↗

FLI-1 is a suppressor of erythroid differentiation in human hematopoietic cellsSemantic proximity Read ↗

Spi-1/PU.1 Transgenic Mice Develop Multistep ErythroleukemiasSemantic proximity Read ↗

EKLF restricts megakaryocytic differentiation at the benefit of erythrocytic differentiationSemantic proximity Read ↗

The ets transcription factor Fli-1 in development, cancer and diseaseSemantic proximity Read ↗

Generation of a novel Fli-1 protein by gene targeting leads to a defect in thymus development and a delay in Friend virus-induced erythroleukemia.Semantic proximity Read ↗

A somatic mutation of GFI1B identified in leukemia alters cell fate via a SPI1 (PU.1) centered genetic regulatory network.Semantic proximity Read ↗

HLS7, a hemopoietic lineage switch gene homologous to the leukemia-inducing gene MLF1.Semantic proximity Read ↗

Molecular Landscapes and Models of Acute ErythroleukemiaSemantic proximity Read ↗

Spi-1 transgenic mice develop a clonal erythroleukemia which does not depend on p53 mutation.Semantic proximity Read ↗

Erythroid Kruppel‐like factor (EKLF) is recruited to the <i>γ</i>‐<i>globin</i> gene promoter as a co‐activator and is required for <i>γ</i>‐<i>globin</i> gene induction by short‐chain fatty acid derivativesSemantic proximity Read ↗

Identification of diterpenoid compounds that interfere with Fli-1 DNA binding to suppress leukemogenesisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.