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Article

Spi-1 and mutant p53 regulate different aspects of the proliferation and differentiation control of primary erythroid progenitors.

Oncogene - 5 Oct 1995

Quang C T, Pironin M, von Lindern M, Beug H, Ghysdael J

Abstract excerpt

The emergence of leukemic cells in Friend virus complex-induced erythroleukemia is associated with two recurrent genetic alterations, namely the inactivation of the p53 tumor suppressor gene and the overexpression of Spi-1, a member of the Ets family of transcriptional regulators. In order to determine the role of these genetic alterations on the proliferation and differentiation control of erythroblasts, we...

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PMID: 7478542

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Spi-1 and mutant p53 regulate different aspects of the proliferation and differentiation control of primary erythroid progenitors.PMID 7478542Read ↗

Spi-1 transgenic mice develop a clonal erythroleukemia which does not depend on p53 mutation.Semantic proximity Read ↗

Endogenous p53 regulation and function in early stage Friend virus-induced tumor progression differs from that following DNA damage.Semantic proximity Read ↗

Spi-1/PU.1 Transgenic Mice Develop Multistep ErythroleukemiasSemantic proximity Read ↗

Regulation of p53-mediated apoptosis and cell cycle arrest by Steel factor.Semantic proximity Read ↗

Growth suppression of Friend virus-transformed erythroleukemia cells by p53 protein is accompanied by hemoglobin production and is sensitive to erythropoietin.Semantic proximity Read ↗

Spi-1/PU.1 Is a Positive Regulator of the Fli-1 Gene Involved in Inhibition of Erythroid Differentiation in Friend Erythroleukemic Cell LinesSemantic proximity Read ↗

Spi-1 and Fli-1 directly activate common target genes involved in ribosome biogenesis in Friend erythroleukemic cells.Semantic proximity Read ↗

Spi-1/PU.1 oncoprotein affects splicing decisions in a promoter binding-dependent manner.Semantic proximity Read ↗

Friend virus induced murine erythroleukaemia: the p53 locus.Semantic proximity Read ↗

Kit-activating mutations cooperate with Spi-1/PU.1 overexpression to promote tumorigenic progression during erythroleukemia in mice.Semantic proximity Read ↗

Sf-Stk kinase activity and the Grb2 binding site are required for Epo-independent growth of primary erythroblasts infected with Friend virus.Semantic proximity Read ↗

The Transcription Factor Spi-1/PU.1 Interacts with the Potential Splicing Factor TLSSemantic proximity Read ↗

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