Spi-1 and mutant p53 regulate different aspects of the proliferation and differentiation control of primary erythroid progenitors.

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Article

Spi-1 and mutant p53 regulate different aspects of the proliferation and differentiation control of primary erythroid progenitors.

Oncogene - 5 Oct 1995

Quang C T, Pironin M, von Lindern M, Beug H, Ghysdael J

Abstract excerpt

The emergence of leukemic cells in Friend virus complex-induced erythroleukemia is associated with two recurrent genetic alterations, namely the inactivation of the p53 tumor suppressor gene and the overexpression of Spi-1, a member of the Ets family of transcriptional regulators. In order to determine the role of these genetic alterations on the proliferation and differentiation control of erythroblasts, we...

Topics

Animals
Base Sequence
Cell Differentiation
Cell Division
Cells, Cultured
Chickens
DNA Primers
DNA-Binding Proteins
Erythroid Precursor Cells
Estradiol
Genes, p53

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Mutation

Retroviridae Proteins, Oncogenic

Stem Cell Factor

Transforming Growth Factor alpha

Tumor Cells, Cultured

Source

Open in PubMed

Identifiers

PMID: 7478542

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7478542-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Spi-1 and mutant p53 regulate different aspects of the proliferation and differentiation control of primary erythroid progenitors.PMID 7478542Read ↗

Spi-1 transgenic mice develop a clonal erythroleukemia which does not depend on p53 mutation.Semantic proximity Read ↗

Endogenous p53 regulation and function in early stage Friend virus-induced tumor progression differs from that following DNA damage.Semantic proximity Read ↗

Spi-1/PU.1 Transgenic Mice Develop Multistep ErythroleukemiasSemantic proximity Read ↗

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Spi-1/PU.1 Is a Positive Regulator of the Fli-1 Gene Involved in Inhibition of Erythroid Differentiation in Friend Erythroleukemic Cell LinesSemantic proximity Read ↗

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