Article
Kit-activating mutations cooperate with Spi-1/PU.1 overexpression to promote tumorigenic progression during erythroleukemia in mice.
Cancer cell - 1 Dec 2005
Kosmider Olivier, Denis Nicole, Lacout Catherine, Vainchenker William, Dubreuil Patrice, Moreau-Gachelin Françoise
Abstract excerpt
The erythroleukemia developed by spi-1/PU.1 transgenic mice is a multistage process characterized by an early arrest of the proerythroblast differentiation followed later on by malignant transformation. Herein, we report the presence of acquired mutations in the SCF receptor gene (Kit) in 86% of tumors isolated during the late stage of the disease. Kit mutations affect codon 814 or 818. Ectopic expression of Kit...
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