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Article

Mutations of the Apc gene in experimental colorectal carcinogenesis induced by azoxymethane in F344 rats.

British journal of cancer - 1 Jun 1998

De Filippo C, Caderni G, Bazzicalupo M, Briani C, Giannini A, Fazi M, Dolara P

Abstract excerpt

We investigated in the rat the role of the Apc gene, which is mutated in familial adenomatous polyposis and sporadic colon cancer in the process leading from normal colonic mucosa to aberrant crypt foci (ACF) and finally to adenomas and adenocarcinomas. We analysed mutations in exon 15 of the rat Apc gene using in vitro synthesized protein assay in 66 ACF and in 28 colon tumours induced by azoxymethane. No Apc...

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Identifiers

PMID: 9649126
DOI: 10.1038/bjc.1998.359
PMCID: PMC2150417

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Mutations of the Apc gene in experimental colorectal carcinogenesis induced by azoxymethane in F344 rats.PMID 9649126Read ↗

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