Article
Mutations of the Apc gene in experimental colorectal carcinogenesis induced by azoxymethane in F344 rats.
British journal of cancer - 1 Jun 1998
De Filippo C, Caderni G, Bazzicalupo M, Briani C, Giannini A, Fazi M, Dolara P
Abstract excerpt
We investigated in the rat the role of the Apc gene, which is mutated in familial adenomatous polyposis and sporadic colon cancer in the process leading from normal colonic mucosa to aberrant crypt foci (ACF) and finally to adenomas and adenocarcinomas. We analysed mutations in exon 15 of the rat...
Topics
- Adenocarcinoma
- Adenoma
- Animals
- Azoxymethane
- Carcinogens
- Cell Transformation, Neoplastic
- Colorectal Neoplasms
- DNA, Neoplasm
- Epithelium
- Genes, APC
- Intestinal Mucosa
- Male
- Mutation
- Polymerase Chain Reaction
- Precancerous Conditions
- Rats
- Rats, Inbred F344