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Article

AOM-induced mouse colon tumors do not express full-length APC protein.

Carcinogenesis - 1 Dec 1997

Maltzman T, Whittington J, Driggers L, Stephens J, Ahnen D

Abstract excerpt

While evidence in both sporadic and inherited human colorectal cancer and MIN mice implicate the tumor suppressor gene, APC, in the causation of colorectal carcinogenesis, this gene has not been confirmed to be involved in rodent chemically-induced colon cancer models (RCCM). These experimental models are widely used to elucidate mechanisms involved in colon carcinogenesis (initiation, promotion and progression)...

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Source

Identifiers

PMID: 9450492
DOI: 10.1093/carcin/18.12.2435

Genes

APC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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