Article
Evidence for a ras gene mutation in azoxymethane-induced colonic aberrant crypts in Sprague-Dawley rats: earliest recognizable precursor lesions of experimental colon cancer.
Carcinogenesis - 1 Nov 1992
Stopera S A, Murphy L C, Bird R P
Abstract excerpt
The main objective of the present investigation was to understand the molecular events involved in the genesis of aberrant crypt foci. Aberrant crypt foci were induced in Sprague-Dawley rats with a single injection of azoxymethane. Aberrant crypts have been identified topographically in the colon and are hypothesized to represent preneoplastic lesions. In order to understand the molecular events involved in the...
Topics
- Adenocarcinoma
- Animals
- Azoxymethane
- Base Sequence
- Colonic Neoplasms
- DNA, Single-Stranded
- Genes, ras
- Immunohistochemistry
- Male
- Molecular Sequence Data
- Mutation