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Article

Accumulation of K-Ras codon 12 mutations in the F344 rat distal colon following azoxymethane exposure.

Environmental and molecular mutagenesis - 1 Jun 2011

McKinzie Page B, Parsons Barbara L

Abstract excerpt

Azoxymethane (AOM) administration to F344 male rats is a widely used model of human colon carcinogenesis. The current study investigates quantitatively the accumulation of K-Ras codon 12 mutations following AOM exposure. Male, 6-week-old F344 rats were treated subcutaneously with 30 mg/kg body weight of AOM, and colon tissue was collected at 1, 8, 24, and 32 weeks after treatment. The K-Ras codon 12 GGT to GAT...

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PMID: 21370285
DOI: 10.1002/em.20644

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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