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Article

Accumulation of K-Ras codon 12 mutations in the F344 rat distal colon following azoxymethane exposure.

Environmental and molecular mutagenesis - 1 Jun 2011

McKinzie Page B, Parsons Barbara L

Abstract excerpt

Azoxymethane (AOM) administration to F344 male rats is a widely used model of human colon carcinogenesis. The current study investigates quantitatively the accumulation of K-Ras codon 12 mutations following AOM exposure. Male, 6-week-old F344 rats were treated subcutaneously with 30 mg/kg body weight of AOM, and colon tissue was collected at 1, 8, 24, and 32 weeks after treatment. The K-Ras codon 12 GGT to GAT...

Topics

Animals
Azoxymethane
Codon
Colon
Genes, ras
Male
Mutation
Polymerase Chain Reaction
Rats
Rats, Inbred F344

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 21370285
DOI: 10.1002/em.20644

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-21370285-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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