Article
Detection of somatic DNA alterations in azoxymethane-induced F344 rat colon tumors by random amplified polymorphic DNA analysis.
Carcinogenesis - 1 Sept 2000
Luceri C, De Filippo C, Caderni G, Gambacciani L, Salvadori M, Giannini A, Dolara P
Abstract excerpt
Colon carcinogenesis induced in rats by azoxymethane (AOM) is a useful experimental model as it mimics the human adenoma-carcinoma sequence and allows the study of dietary variation and of the effects of chemopreventive substances. Alterations of specific oncogenes and tumor suppressor genes (APC...
Topics
- Adenocarcinoma
- Adenoma
- Animals
- Azoxymethane
- Carcinogens
- Colonic Neoplasms
- DNA Damage
- DNA Fingerprinting
- DNA, Neoplasm
- Genes, ras
- Male
- Microsatellite Repeats
- Mutation
- Precancerous Conditions
- Random Amplified Polymorphic DNA Technique
- Rats
- Rats, Inbred F344