Altered expression of beta-catenin, inducible nitric oxide synthase and cyclooxygenase-2 in azoxymethane-induced rat colon carcinogenesis.

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Altered expression of beta-catenin, inducible nitric oxide synthase and cyclooxygenase-2 in azoxymethane-induced rat colon carcinogenesis.

Carcinogenesis - 1 Jul 2000

Takahashi M, Mutoh M, Kawamori T, Sugimura T, Wakabayashi K

Abstract excerpt

Activation of the beta-catenin/T cell factor-mediated transcription pathway through mutations of the APC or beta-catenin gene is suggested to play an important role in colon carcinogenesis and there is great interest in the target genes. We have described the frequent mutation and an altered cellular localization of beta-catenin in rat colon adenocarcinomas induced by azoxymethane (AOM), along with up-regulation...

Topics

Adenocarcinoma
Adenoma
Animals
Azoxymethane
Carcinogens
Colonic Neoplasms
Cyclooxygenase 2
Cytoskeletal Proteins
Gene Expression
Genes, ras
Hyperplasia

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Isoenzymes

Male

Mutation

Nitric Oxide Synthase

Nitric Oxide Synthase Type II

Polymerase Chain Reaction

Polymorphism, Single-Stranded Conformational

Source

Open in PubMed

Identifiers

PMID: 10874009

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Altered expression of beta-catenin, inducible nitric oxide synthase and cyclooxygenase-2 in azoxymethane-induced rat colon carcinogenesis.PMID 10874009Read ↗

Gene mutations and altered gene expression in azoxymethane-induced colon carcinogenesis in rodents.Semantic proximity Read ↗

Mutational and nonmutational activation of p21ras in rat colonic azoxymethane-induced tumors: effects on mitogen-activated protein kinase, cyclooxygenase-2, and cyclin D1.Semantic proximity Read ↗

Beta-Catenin mutations in a mouse model of inflammation-related colon carcinogenesis induced by 1,2-dimethylhydrazine and dextran sodium sulfate.Semantic proximity Read ↗

The signal pathways in azoxymethane-induced colon cancer and preventive implicationsSemantic proximity Read ↗

Gene expression profile and genomic alterations in colonic tumours induced by 1,2-dimethylhydrazine (DMH) in ratsSemantic proximity Read ↗

Frequent mutations of the beta-catenin gene in mouse colon tumors induced by azoxymethane.Semantic proximity Read ↗

Reduced expression level of mgmt mRNA and beta-catenin gene mutation in rat colon tumors.Semantic proximity Read ↗

beta-Catenin mutation is selected during malignant transformation in colon carcinogenesis.Semantic proximity Read ↗

Nonsteroidal anti-inflammatory drug-activated gene-1 over expression in transgenic mice suppresses intestinal neoplasia.Semantic proximity Read ↗

Aberrant DNA methylation occurs in colon neoplasms arising in the azoxymethane colon cancer modelSemantic proximity Read ↗

Genetic signatures of high- and low-risk aberrant crypt foci in a mouse model of sporadic colon cancer.Semantic proximity Read ↗

Modulation of azoxymethane-induced mutational activation of ras protooncogenes by chemopreventive agents in colon carcinogenesis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.