beta-Catenin mutation is selected during malignant transformation in colon carcinogenesis.

doi:10.1093/carcin/24.1.91

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Article

beta-Catenin mutation is selected during malignant transformation in colon carcinogenesis.

Carcinogenesis - 1 Jan 2003

Yamada Yasuhiro, Oyama Takeru, Hirose Yoshinobu, Hara Akira, Sugie Shigeyuki, Yoshida Koujiro, Yoshimi Naoki, Mori Hideki

Abstract excerpt

Activating mutations in the beta-catenin gene is thought to be responsible for the excessive beta-catenin signaling involved in the majority of colon carcinomas in rodent models. Our recent study which indicated that beta-catenin mutations are present frequently in early dysplastic lesions of rat...

Topics

Animals
Base Sequence
Cell Transformation, Neoplastic
Colonic Neoplasms
Cytoskeletal Proteins
Genes, ras
Immunohistochemistry
Male
Molecular Sequence Data
Mutation
Rats
Rats, Inbred F344
Trans-Activators
beta Catenin

Source

Open in PubMed

Identifiers

PMID: 12538353
DOI: 10.1093/carcin/24.1.91

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-12538353-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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