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Article

beta-Catenin mutation is selected during malignant transformation in colon carcinogenesis.

Carcinogenesis - 1 Jan 2003

Yamada Yasuhiro, Oyama Takeru, Hirose Yoshinobu, Hara Akira, Sugie Shigeyuki, Yoshida Koujiro, Yoshimi Naoki, Mori Hideki

Abstract excerpt

Activating mutations in the beta-catenin gene is thought to be responsible for the excessive beta-catenin signaling involved in the majority of colon carcinomas in rodent models. Our recent study which indicated that beta-catenin mutations are present frequently in early dysplastic lesions of rat colon induced by a colon-specific carcinogen, azoxymethane led us to perform more specifically a comparative study...

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Identifiers

PMID: 12538353
DOI: 10.1093/carcin/24.1.91

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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