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Article

Evolution of Hypervariable Region 1 of Hepatitis C Virus in Primary Infection

1 Jul 1998

Abstract excerpt

The hypervariable region 1 (HVR-1) of the putative envelope encoding E2 region of hepatitis C virus (HCV) RNA was analyzed in sequential samples from three patients with acute type C hepatitis infected from different sources to address (i) the dynamics of intrahost HCV variability during the primary infection and (ii) the role of host selective pressure in driving viral genetic evolution. HVR-1 sequences from 20...

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Identifiers

PMID: 9621104
DOI: 10.1128/jvi.72.7.6271-6276.1998

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