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Article

Intra-host viral population dynamics during acute hepatitis E virus infection.

mBio - 12 Aug 2026

Janshoff Saskia, Plümers Ricarda, Kohl Alina, Nocke Maximilian Klaus, Behrendt Patrick, Knabbe Cornelius, Costa Rui, Vollmer Tanja, Todt Daniel, Steinmann Eike, Gömer Andre

Abstract excerpt

The hepatitis E virus (HEV) is the most common cause of acute viral hepatitis worldwide. RNA viruses like HEV can establish viral populations with high intra-host variability, enabling them to rapidly adapt to changing immune responses, as observed in chronic infections. This study aimed to investigate how intra-host evolution shapes HEV populations during acute asymptomatic infection. Using a highly sensitive...

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Blood Donors
Evolution, Molecular
Genetic Variation
Genome, Viral
Hepatitis E

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Hepatitis E virus

Virus Replication

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Identifiers

PMID: 42429402
DOI: 10.1128/mbio.01151-26
PMCID: PMC13463781

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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