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Article

Comparative Analysis of Within-Host Mutation Patterns and Diversity of Hepatitis C Virus Subtypes 1a, 1b, and 3a.

Viruses - 19 Mar 2021

Tisthammer Kaho H, Dong Weiyan, Joy Jeffrey B, Pennings Pleuni S

Abstract excerpt

Understanding within-host evolution is critical for predicting viral evolutionary outcomes, yet such studies are currently lacking due to difficulty involving human subjects. Hepatitis C virus (HCV) is an RNA virus with high mutation rates. Its complex evolutionary dynamics and extensive genetic diversity are demonstrated in over 67 known subtypes. In this study, we analyzed within-host mutation frequency...

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Identifiers

PMID: 33808782
DOI: 10.3390/v13030511
PMCID: PMC8003410

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