Article
Dynamics of hypervariable region 1 variation in hepatitis C virus infection and correlation with clinical and virological features of liver disease.
Hepatology (Baltimore, Md.) - 1 Jun 1998
Brambilla S, Bellati G, Asti M, Lisa A, Candusso M E, D'Amico M, Grassi G, Giacca M, Franchini A, Bruno S, Ideo G, Mondelli M U, Silini E M
Abstract excerpt
Hepatitis C virus (HCV) infection is a dynamic process during which molecular variants are continuously selected as the result of virus adaptation to the host. Understanding the nature of HCV genetic variation is central to current theories of pathogenesis and immune response. We prospectively studied hypervariable region 1 (HVR1) variation in the E2 gene of 36 hepatitis C patients, including 10 asymptomatic...
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