Article
Selective sensitivity to radiation of cerebral glioblastomas harboring p53 mutations.
Cancer research - 1 May 1998
Tada M, Matsumoto R, Iggo R D, Onimaru R, Shirato H, Sawamura Y, Shinohe Y
Abstract excerpt
Recent studies suggest that a balance may exist between the cell cycle arrest and apoptosis-inducing functions of the p53 tumor suppressor gene. Adenoviral p21 transduction attenuates apoptosis, whereas deletion of the p21 gene promotes it, and p21-null xenografts respond better than isogenic p21-wild type tumors to irradiation. Hence, the role of p53 in dictating the clinical response to radiotherapy and...
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