Enhancement of radiosensitivity of wild-type p53 human glioma cells by adenovirus-mediated delivery of the p53 gene.

doi:10.3171/jns.1998.89.1.0125

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Article

Enhancement of radiosensitivity of wild-type p53 human glioma cells by adenovirus-mediated delivery of the p53 gene.

Journal of neurosurgery - 1 Jul 1998

Lang F F, Yung W K, Raju U, Libunao F, Terry N H, Tofilon P J

Abstract excerpt

OBJECT: The authors sought to determine whether combining p53 gene transfer with radiation therapy would enhance the therapeutic killing of p53 wild-type glioma cells. It has been shown in several reports that adenovirus-mediated delivery of the p53 gene into p53 mutant gliomas results in dramati...

Topics

Adenoviridae
Alleles
Apoptosis
Blotting, Western
Brain Neoplasms
Cell Division
Cell Survival
Coloring Agents
Culture Media
Dose-Response Relationship, Radiation
Flow Cytometry
Gene Expression Regulation, Neoplastic
Gene Transfer Techniques
Genes, p53
Genetic Vectors
Glioma
Humans
Mutation

Source

Open in PubMed

Identifiers

PMID: 9647183
DOI: 10.3171/jns.1998.89.1.0125

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9647183-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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