Article
[Clinical and pathological significance of p53 gene mutation in human cerebral glioblastoma multiforme].
[Hokkaido igaku zasshi] The Hokkaido journal of medical science - 1 Jul 1998
Matsumoto R
Abstract excerpt
Cerebral glioblastomas multiforme (GMs), the most malignant human primary brain tumor, molecular genetically comprise two subsets characterized by p53 tumor suppressor gene status. One is characterized by p53 mutation and another is with wild-type p53 and overexpression of epidermal growth factor...
Topics
- Adolescent
- Adult
- Age of Onset
- Aged
- Brain Neoplasms
- Child
- Child, Preschool
- ErbB Receptors
- Female
- Genes, p53
- Glioblastoma
- Humans
- Immunohistochemistry
- Male
- Middle Aged
- Mutation
- Prognosis
- Regression Analysis