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P21 Overexpression Promotes Cell Death and Induces Senescence in Human Glioblastoma

17 Feb 2023

Abstract excerpt

High-grade gliomas are the most common and aggressive adult primary brain tumors with a median survival of only 12-15 months. Current standard therapy consists of maximal safe surgical resection followed by DNA-damaging agents, such as irradiation and chemotherapy that can delay but not prevent inevitable recurrence. Some have interpreted glioma recurrence as evidence of glioma stem cells which persist in a...

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PMID: 36831620
DOI: 10.3390/cancers15041279

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