Article

P21 Overexpression Promotes Cell Death and Induces Senescence in Human Glioblastoma

2022-12-23

Abstract excerpt

High-grade gliomas are the most common and aggressive adult primary brain tumors with a median survival of only 12-15 months. Current standard therapy consists of maximal safe surgical resection followed by DNA-damaging agents, such as irradiation and chemotherapy that can delay but not prevent inevitable recurrence. Some have interpreted glioma recurrence as evidence of glioma stem cells which persist in a relati...

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Literature Corpus work: 5978cb9c-131d-55e1-994b-70062d91308e
DOI: 10.20944/preprints202212.0442.v1

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