Article
Radiosensitivity of canine osteosarcoma cells transfected with wild-type p53 in vitro.
Veterinary and comparative oncology - 1 Sept 2008
Shiomitsu K, Sajo E, Xia X, Hunley D W, Mauldin G E, Li S, Mauldin G N
Abstract excerpt
The p53 gene is one of the important tumour suppressor genes that are involved with the cell survival signal pathway. One of the major functions of the p53 protein is to organize cell cycle regulation and induction of apoptosis for cellular genetic stability. It has been documented that more than 50% of all human cancers include a p53 mutation. We evaluated the difference in radiosensitivity between upregulating...
Topics
- Animals
- Cell Line, Tumor
- Dogs
- Dose-Response Relationship, Radiation
- Genes, p53
- Mutation
- Osteosarcoma
- Radiation Tolerance
- Up-Regulation