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Adenovirus-mediatedp53 gene transfer suppresses growth of human glioblastoma cellsin vitro andin vivo

17 Sept 1996

Abstract excerpt

Alterations in the p53 tumor-suppressor gene occur in 35-60% of human glioblastomas, and re-introduction of p53 can suppress neoplastic growth. To evaluate the potential for p53 gene therapy of glioblastoma, we have analyzed the response of human glioblastoma cell lines in vitro and in vivo to experimental therapy with replication-deficient recombinant adenoviruses encoding wild-type p53 (rAd-p53). Western blot...

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PMID: 8824552
DOI: 10.1002/(sici)1097-0215(19960917)67:6<808::aid-ijc9>3.0.co;2-v

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Source receipt: pubmed, retrieved 7 Sept 2026.

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