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Article

High frequency of temperature-sensitive mutants of p53 in glioblastoma.

Pathology oncology research : POR - 1 Jul 2013

Smardova Jana, Liskova Kvetoslava, Ravcukova Barbora, Kubiczkova Lenka, Sevcikova Sabina, Michalek Jaroslav, Svitakova Miluse, Vybihal Vaclav, Kren Leos, Smarda Jan

Abstract excerpt

Glioblastoma is the most common and the most aggressive type of brain cancer. Aberrations of the RTK/RAS/PI3K-, p53-, and RB cell signaling pathways were recognized as a core requirement for pathogenesis of glioblastoma. The p53 tumor suppressor functions as a transcription factor transactivating expression of its target genes in response to various stress stimuli. We determined the p53 status in 36 samples of...

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Identifiers

PMID: 23536279
DOI: 10.1007/s12253-012-9596-7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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