[Functional restoration of tumor suppressor p53 alters susceptibility of glioblastoma cells to irradiation--analysis using a cell line containing a temperature-sensitive mutant].

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Article

[Functional restoration of tumor suppressor p53 alters susceptibility of glioblastoma cells to irradiation--analysis using a cell line containing a temperature-sensitive mutant].

[Hokkaido igaku zasshi] The Hokkaido journal of medical science - 1 Jul 2000

Tsuchiya K

Abstract excerpt

To examine the functional role of tumor suppressor p53 in radiosensitivity of glioblastoma multiforme cells, I analyzed radiosensitivity of three glioblastoma cell lines with different p53 statuses: LN444 (wild-type p53), U251MG (mutant R273Q), and LN382 (mutant V197L). The mutant V197L is a temperature-sensitive (ts) mutant, of which transcriptional activity is almost normal at 34 degrees C but lost at 37...

Topics

Cell Cycle
Child
Genes, p53
Glioblastoma
Humans
Mutation
Oncogene Protein p21(ras)
Proto-Oncogene Proteins
Proto-Oncogene Proteins c-bcl-2
Radiation Tolerance
Temperature
Tumor Cells, Cultured
bcl-2-Associated X Protein

Source

Open in PubMed

Identifiers

PMID: 10976406

Provenance

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