Article
Use of wild-type p53 to achieve complete treatment sensitization of tumor cells expressing endogenous mutant p53.
Molecular carcinogenesis - 1 Dec 1995
Gjerset R A, Turla S T, Sobol R E, Scalise J J, Mercola D, Collins H, Hopkins P J
Abstract excerpt
It is known that transfer of the wild-type p53 gene into p53-negative cells from transgenic mice increases their sensitivity to drug and radiation-induced apoptosis. However, unlike many human tumors, these transgenic cells do not express mutant p53, and it is not known from these earlier studies...
Topics
- Antineoplastic Agents
- Apoptosis
- Base Sequence
- Cisplatin
- Clone Cells
- Drug Screening Assays, Antitumor
- Gene Transfer Techniques
- Genes, p53
- Glioblastoma
- Humans
- Molecular Sequence Data
- Mutation
- Radiation Tolerance
- Transduction, Genetic
- Tumor Cells, Cultured