Article
Use of wild-type p53 to achieve complete treatment sensitization of tumor cells expressing endogenous mutant p53.
Molecular carcinogenesis - 1 Dec 1995
Gjerset R A, Turla S T, Sobol R E, Scalise J J, Mercola D, Collins H, Hopkins P J
Abstract excerpt
It is known that transfer of the wild-type p53 gene into p53-negative cells from transgenic mice increases their sensitivity to drug and radiation-induced apoptosis. However, unlike many human tumors, these transgenic cells do not express mutant p53, and it is not known from these earlier studies whether wild-type p53 dominates the effects of mutant p53 with respect to drug and radiation sensitivity. We addressed...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.