Cell cycle synchrony unmasks the influence of p53 function on radiosensitivity of human glioblastoma cells.

Article

Cell cycle synchrony unmasks the influence of p53 function on radiosensitivity of human glioblastoma cells.

Cancer research - 1 Feb 1996

Yount G L, Haas-Kogan D A, Vidair C A, Haas M, Dewey W C, Israel M A

Abstract excerpt

Although ionizing radiation causes DNA damage that can play a role in tumorigenesis, such irradiation is also an important modality of cancer therapy. We studied the radiation response of the U-87 MG human glioblastoma cell line and transfected derivatives in which p53 function had been inactivat...

Topics

Cell Cycle
G1 Phase
Gene Expression Regulation, Neoplastic
Genes, p53
Glioblastoma
Humans
Mutation
Radiation Tolerance
Tumor Cells, Cultured
Tumor Suppressor Protein p53

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