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Article

Contributions of the TATA box sequence to rate-limiting steps in transcription initiation by RNA polymerase II.

Journal of molecular biology - 17 Apr 1998

Hoopes B C, LeBlanc J F, Hawley D K

Abstract excerpt

We have examined the role of the TATA box in determining transcription initiation frequency in vitro by studying a collection of promoters containing different TATA sequences in the context of the adenovirus major late promoter. In addition to measuring transcription rates, we have determined how the sequence changes affected the association and dissociation kinetics and the affinity of TBP binding. We observed...

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Source

Identifiers

PMID: 9571019
DOI: 10.1006/jmbi.1998.1651

Genes

TBP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Contributions of the TATA box sequence to rate-limiting steps in transcription initiation by RNA polymerase II.PMID 9571019Read ↗

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TFIID can be rate limiting in vivo for TATA-containing, but not TATA-lacking, RNA polymerase II promoters.Semantic proximity Read ↗

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Spacing requirements for simultaneous recognition of the adenovirus major late promoter TATAAAAG box and initiator element.Semantic proximity Read ↗

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