Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The sequence at specific positions in the early transcribed region sets the rate of transcript synthesis by RNA polymerase II in vitro.

The Journal of biological chemistry - 2 Dec 2005

Weaver Jessica R, Kugel Jennifer F, Goodrich James A

Abstract excerpt

To further understand the mechanism of promoter escape by RNA polymerase II, we have systematically investigated the effect of core promoter sequence on the rate of transcript synthesis in vitro. Chimeric and mutant promoters were made by swapping sequences between the human interleukin-2 promoter and the adenovirus major late promoter, which exhibit different rates of transcript synthesis. Kinetic studies at...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenoviridae
Share to In Vitro Techniques

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Interleukin-2

Share to Kinetics

Share to Recombinant Fusion Proteins

Share to Recombinant Proteins

Share to RNA Polymerase II

Share to Thermodynamics

Source

Identifiers

PMID: 16210313
DOI: 10.1074/jbc.M509376200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The sequence at specific positions in the early transcribed region sets the rate of transcript synthesis by RNA polymerase II in vitro.PMID 16210313Read ↗

An alternate mechanism of abortive release marked by the formation of very long abortive transcripts.Semantic proximity Read ↗

Sequential release of promoter contacts during transcription initiation to elongation transition.Semantic proximity Read ↗

mRNA 5′ terminal sequences drive 200-fold differences in expression through effects on synthesis, translation and decaySemantic proximity Read ↗

Contributions of the TATA box sequence to rate-limiting steps in transcription initiation by RNA polymerase II.Semantic proximity Read ↗

Specific initiation and switch to elongation of human immunodeficiency virus type 1 reverse transcription require the post‐transcriptional modifications of primer tRNA3Lys.Semantic proximity Read ↗

The low processivity of T7 RNA polymerase over the initially transcribed sequence can limit productive initiation in vivo.Semantic proximity Read ↗

Interplay between σ region 3.2 and secondary channel factors during promoter escape by bacterial RNA polymerase.Semantic proximity Read ↗

Temporal regulation of adenovirus major late alternative RNA splicingSemantic proximity Read ↗

Characteristics of a novel activator of RNA polymerase II transcription.Semantic proximity Read ↗

Single-allele analysis of transcription kinetics in living mammalian cells.Semantic proximity Read ↗

Transcription from the adenovirus major late promoter uses redundant activating elements.Semantic proximity Read ↗

The Respiratory Syncytial Virus Polymerase Has Multiple RNA Synthesis Activities at the PromoterSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.