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Article

A transcription factor IIA-binding site differentially regulates RNA polymerase II-mediated transcription in a promoter context-dependent manner.

The Journal of biological chemistry - 14 Jul 2017

Wang Juan, Zhao Shasha, He Wei, Wei Yun, Zhang Yang, Pegg Henry, Shore Paul, Roberts Stefan G E, Deng Wensheng

Abstract excerpt

RNA polymerase II (pol II) is required for the transcription of all protein-coding genes and as such represents a major enzyme whose activity is tightly regulated. Transcriptional initiation therefore requires numerous general transcriptional factors and cofactors that associate with pol II at the core promoter to form a pre-initiation complex. Transcription factor IIA (TFIIA) is a general cofactor that binds...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28539359
DOI: 10.1074/jbc.M116.770412
PMCID: PMC5512080

Genes

TAF4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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A transcription factor IIA-binding site differentially regulates RNA polymerase II-mediated transcription in a promoter context-dependent manner.PMID 28539359Read ↗

Disruption of the interaction between TFIIAαβ and TFIIA recognition element inhibits RNA polymerase II gene transcription in a promoter context-dependent manner.Semantic proximity Read ↗

Characterization of Transcription from TATA-Less Promoters: Identification of a New Core Promoter Element XCPE2 and Analysis of Factor RequirementsSemantic proximity Read ↗

The New Core Promoter Element XCPE1 (X Core Promoter Element 1) Directs Activator-, Mediator-, and TATA-Binding Protein-Dependent but TFIID-Independent RNA Polymerase II Transcription from TATA-Less PromotersSemantic proximity Read ↗

Direct recognition of initiator elements by a component of the transcription factor IID complex.Semantic proximity Read ↗

Activator-mediated disruption of sequence-specific DNA contacts by the general transcription factor TFIIB.Semantic proximity Read ↗

Requirement for transcription factor IIA (TFIIA)-TFIID recruitment by an activator depends on promoter structure and template competition.Semantic proximity Read ↗

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Core promoter elements and TAFs contribute to the diversity of transcriptional activation in vertebrates.Semantic proximity Read ↗

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Transcription factor IIB acetylates itself to regulate transcription.Semantic proximity Read ↗

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