Adenovirus E1A activation domain binds the basic repeat in the TATA box transcription factor.

doi:10.1016/0092-8674(91)90188-5

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Adenovirus E1A activation domain binds the basic repeat in the TATA box transcription factor.

Cell - 18 Oct 1991

Lee W S, Kao C C, Bryant G O, Liu X, Berk A J

Abstract excerpt

The adenovirus large E1A protein is a potent activator of transcription. We use several different experimental approaches to demonstrate that the large E1A protein binds specifically and stably to the TATA box-binding factor (TFIID), the general polymerase II transcription factor that initiates assembly of transcription complexes. Sedimentation velocity centrifugation revealed that TFIID and E1A form a...

Topics

Adenoviridae
Adenovirus Early Proteins
Amino Acid Sequence
Binding Sites
Blotting, Western
Escherichia coli
HeLa Cells
Humans
Macromolecular Substances
Molecular Sequence Data
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Oncogene Proteins, Viral

Recombinant Fusion Proteins

TATA Box

Transcription Factor TFIID

Transcription Factors

Transcription, Genetic

Vaccinia virus

Source

Open in PubMed

Identifiers

PMID: 1833071
DOI: 10.1016/0092-8674(91)90188-5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1833071-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Adenovirus E1A activation domain binds the basic repeat in the TATA box transcription factor.PMID 1833071Read ↗

Analysis of DNA binding by the adenovirus type 5 E1A oncoprotein.Semantic proximity Read ↗

A TATA box implicated in E1A transcriptional activation of a simple adenovirus 2 promoter.Semantic proximity Read ↗

Mutational and functional analysis of an essential subdomain of the adenovirus E1A N-terminal transcription repression domain.Semantic proximity Read ↗

Adenovirus protein VII binds the A-box of HMGB1 to repress interferon responsesSemantic proximity Read ↗

Unique TATA-binding protein-containing complexes and cofactors involved in transcription by RNA polymerases II and III.Semantic proximity Read ↗

Promoter targeting by adenovirus E1a through interaction with different cellular DNA-binding domainsSemantic proximity Read ↗

Adenovirus E1A Targets the DREF Nuclear Factor To Regulate Virus Gene Expression, DNA Replication, and GrowthSemantic proximity Read ↗

Identification of a second CtBP binding site in adenovirus type 5 E1A conserved region 3.Semantic proximity Read ↗

Biochemical characterization of the TATA-binding protein-Gal4 activation domain complex.Semantic proximity Read ↗

Contributions of the TATA box sequence to rate-limiting steps in transcription initiation by RNA polymerase II.Semantic proximity Read ↗

A specific member of the ATF transcription factor family can mediate transcription activation by the adenovirus E1a protein.Semantic proximity Read ↗

Functional knockout of the corepressor CtBP by the second exon of adenovirus E1a relieves repression of transcription.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.