Article
Apoptosis was promoted at a nonpermissive temperature in DNA replication-defective temperature-sensitive mutants of mouse FM3A cells.
Experimental cell research - 1 Feb 1998
Yamauchi Y, Tanaka A, Yamaguchi K, Kobayashi M, Shimamura S, Hanaoka F
Abstract excerpt
Apoptosis was promoted at the nonpermissive temperature in some temperature-sensitive (ts) mutant strains of mouse FM3A cells deficient in initiation of DNA replication. We examined expression of cell cycle regulation genes in the four ts mutant strains and found that two strains, tsFT107 and tsF...
Topics
- Animals
- Apoptosis
- Carcinoma
- Cell Cycle
- Cell Line
- Cell Survival
- Cyclin A
- Cyclin D1
- Cyclin-Dependent Kinase Inhibitor p21
- Cyclins
- DNA Fragmentation
- DNA Replication
- Mammary Neoplasms, Experimental
- Mice
- Mutation
- Phosphorylation
- Proto-Oncogene Proteins
- Proto-Oncogene Proteins c-bcl-2