Transfection of p53-knockout mouse fibroblasts with wild-type p53 increases the thermosensitivity and stimulates apoptosis induced by heat stress.

doi:10.1016/s0360-3016(97)00149-1

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Article

Transfection of p53-knockout mouse fibroblasts with wild-type p53 increases the thermosensitivity and stimulates apoptosis induced by heat stress.

International journal of radiation oncology, biology, physics - 1 Aug 1997

Matsumoto H, Takahashi A, Wang X, Ohnishi K, Ohnishi T

Abstract excerpt

PURPOSE: The relationship between the p53 functions and cellular thermosensitivity was evaluated using murine fibroblasts transfected with either wild-type p53 or mutated p53, or those with a null p53 genotype. METHODS AND MATERIALS: Cellular thermosensitivity was determined using the clonogenic...

Topics

Animals
Apoptosis
Cell Cycle
Cell Nucleus
Cell Survival
Fibroblasts
G1 Phase
Genes, p53
Genotype
Hot Temperature
Hyperthermia, Induced
Mice
Mice, Knockout
Transfection
Tumor Suppressor Protein p53

Source

Open in PubMed

Identifiers

PMID: 9300755
DOI: 10.1016/s0360-3016(97)00149-1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9300755-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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