Article
Conditional resistance to thymineless death predominantly selects DNA synthesis-deficient mutants of mammalian cells.
Mutation research - 1 Sept 1993
Yamao F, Nagai Y, Kaneda S, Yoshida S, Seno T
Abstract excerpt
Temperature-sensitive growth mutants of the mouse mammary carcinoma cell line FM3A were isolated by selecting survivors of thymidylate starvation for a limited time at the restrictive temperature (39.5 degrees C). Nineteen lines of independent isolates were established and all were found to be deficient in DNA synthesis. Cell-cell hybridization with authentic mutant lines of FM3A demonstrated that the mutants...
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