Article
Incubation at the nonpermissive temperature induces deficiencies in UV resistance and mutagenesis in mouse mutant cells expressing a temperature-sensitive ubiquitin-activating enzyme (E1).
Molecular and cellular biology - 1 Mar 1997
Ikehata H, Kaneda S, Yamao F, Seno T, Ono T, Hanaoka F
Abstract excerpt
In temperature-sensitive (ts) mutants of mouse FM3A cells, the levels of mutagenesis and survival of cells treated with DNA-damaging agents have been difficult to assess because they are killed after their mutant phenotypes are expressed at the nonpermissive temperature. To avoid this difficulty,...
Topics
- Animals
- CDC2 Protein Kinase
- Carcinoma
- DNA Damage
- DNA Polymerase II
- DNA Repair
- Ligases
- Mammary Neoplasms, Experimental
- Mice
- Mutagenesis
- Mutagens
- Mutation