Article
Temperature-sensitive mutation of DNA polymerase alpha induces growth-suppressive phenotypes involving retinoblastoma protein and cyclin D1.
Cell structure and function - 1 Aug 1995
Yamaguchi K, Kobayashi M, Yamauchi Y, Tanaka A, Miyazawa H, Izumi M, Hanaoka F
Abstract excerpt
Temperature-sensitive (ts) cell cycle mutant mouse cell, tsFT20, is deficient in DNA polymerase alpha activity to initiate DNA replication at replicon origins. Here, we analyzed phenotypes concerning growth control genes in the arrested tsFT20 cells. Analysis of cyclins showed that expression levels of cyclin D1, which is essential for G1/S transition, remarkably decreased in the mutant cells after temperature...
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