Article
Temperature-sensitive mutation of DNA polymerase alpha induces growth-suppressive phenotypes involving retinoblastoma protein and cyclin D1.
Cell structure and function - 1 Aug 1995
Yamaguchi K, Kobayashi M, Yamauchi Y, Tanaka A, Miyazawa H, Izumi M, Hanaoka F
Abstract excerpt
Temperature-sensitive (ts) cell cycle mutant mouse cell, tsFT20, is deficient in DNA polymerase alpha activity to initiate DNA replication at replicon origins. Here, we analyzed phenotypes concerning growth control genes in the arrested tsFT20 cells. Analysis of cyclins showed that expression lev...
Topics
- Animals
- Base Sequence
- Cell Division
- Cyclin D1
- Cyclins
- DNA Polymerase II
- Mice
- Molecular Sequence Data
- Mutation
- Oncogene Proteins
- RNA, Messenger
- Retinoblastoma
- Retinoblastoma Protein
- Temperature
- Tumor Cells, Cultured