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Article

Transfection of p53-knockout mouse fibroblasts with wild-type p53 increases the thermosensitivity and stimulates apoptosis induced by heat stress.

International journal of radiation oncology, biology, physics - 15 Jul 1997

Matsumoto H, Takahashi A, Wang X, Ohnishi K, Ohnishi T

Abstract excerpt

PURPOSE: The relationship between p53 functions and cellular thermosensitivity was evaluated using murine fibroblasts transfected with either wild-type p53 or mutated p53, or those with a null p53 genotype. METHODS AND MATERIALS: Cellular thermosensitivity was determined using the clonogenic assay. Cell cycle distribution was assayed by determining DNA content using flow cytometry. Apoptosis was analyzed by...

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PMID: 9276376
DOI: 10.1016/s0360-3016(97)00300-3

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