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Article

Relationship between thermal tolerance and protein degradation in temperature-sensitive mouse cells.

Journal of cellular physiology - 1 May 1992

Li J J, Dewey W C

Abstract excerpt

The induction of thermotolerance was studied in a temperature sensitive mouse cell line, ts85, and results were compared with those for the wild-type FM3A cells. At the nonpermissive temperature of 39 degrees C, ts85 cells are defective in the degradation of short-lived abnormal proteins, apparently because of loss of activity of a ubiquitin-activating enzyme. The failure of the ts85 cells to develop...

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Identifiers

PMID: 1572905
DOI: 10.1002/jcp.1041510212

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Relationship between thermal tolerance and protein degradation in temperature-sensitive mouse cells.PMID 1572905Read ↗

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Incubation at the nonpermissive temperature induces deficiencies in UV resistance and mutagenesis in mouse mutant cells expressing a temperature-sensitive ubiquitin-activating enzyme (E1).Semantic proximity Read ↗

The ubiquitin-activating enzyme is required for lysosomal degradation of cellular proteins under stress.Semantic proximity Read ↗

Impaired induction of heat shock protein implicated in decreased thermotolerance in a temperature-sensitive multinucleated cell line.Semantic proximity Read ↗

Complementation by a cloned human ubiquitin-activating enzyme E1 of the S-phase-arrested mouse FM3A cell mutant with thermolabile E1.Semantic proximity Read ↗

Apoptosis was promoted at a nonpermissive temperature in DNA replication-defective temperature-sensitive mutants of mouse FM3A cells.Semantic proximity Read ↗

Effects of culture temperature on the expression of heat-shock proteins in murine ts85 cells.Semantic proximity Read ↗

Induction of heat shock protein and thermal sensitivity of mammalian cells maintained at low culture temperature.Semantic proximity Read ↗

Molecular characterization of the thermosensitive E1 ubiquitin-activating enzyme cell mutant A31N-ts20. Requirements upon different levels of E1 for the ubiquitination/degradation of the various protein substrates in vivo.Semantic proximity Read ↗

Immunoaffinity-purified DNA polymerase alpha from a mouse temperature-sensitive mutant, tsFT20 strain, is heat-labile.Semantic proximity Read ↗

Characterization of DNA synthesis at a restrictive temperature in the temperature-sensitive mutants, tsFT5 cells, that belong to the complementation group of ts85 cells containing a thermolabile ubiquitin-activating enzyme E1. Involvement of the ubiquitin-conjugating system in DNA replication.Semantic proximity Read ↗

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