A hamster temperature-sensitive alanyl-tRNA synthetase mutant causes degradation of cell-cycle related proteins and apoptosis.

doi:10.1093/jb/mvh001

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Article

A hamster temperature-sensitive alanyl-tRNA synthetase mutant causes degradation of cell-cycle related proteins and apoptosis.

Journal of biochemistry - 1 Jan 2004

Wang Yonggang, Sekiguchi Takeshi, Noguchi Eishi, Nishimoto Takeharu

Abstract excerpt

We have isolated a temperature-sensitive alanyl-tRNA synthetase mutant from hamster BHK21 cells, designated as ts ET12. It has a single nucleotide mutation, converting the 321st amino acid residue, 321Gly, to Arg. The mutation was localized between two RNA-binding domains of alanyl-tRNA synthetase. Thus far, we have isolated two temperature-sensitive aminoacyl-tRNA synthetase mutants from the BHK21 cell line: ts...

Topics

Alanine-tRNA Ligase
Amino Acid Sequence
Animals
Apoptosis
Cell Cycle Proteins
Cell Line
Cricetinae
Humans
Molecular Sequence Data
Mutation
Temperature

Source

Open in PubMed

Identifiers

PMID: 14999004
DOI: 10.1093/jb/mvh001

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