Article
Expression of E-cadherin and its relation to the p53 protein status in human breast carcinomas.
Virchows Archiv : an international journal of pathology - 1 Nov 1997
Bukholm I K, Nesland J M, Kåresen R, Jacobsen U, Børresen-Dale A L
Abstract excerpt
In breast carcinomas the TP53 gene is altered in 10-30% of cases. Alteration of the gene may lead to a general genomic instability, detected as deletions and/or amplifications at the gene level, and as altered expression at the mRNA and protein level. We have demonstrated a strong association between down-regulation of E-cadherin protein expression and alterations of the p53 protein, detected as TP53 gene...
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