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Article

p53 gene mutations and expression of p53 and mdm2 proteins in invasive breast carcinoma. A comparative analysis with clinico-pathological factors.

Journal of cancer research and clinical oncology - 1 Jan 1997

Günther T, Schneider-Stock R, Rys J, Niezabitowski A, Roessner A

Abstract excerpt

The aim of the study was to analyze p53 gene mutations and the expression of p53 and mdm2 proteins in 31 randomly selected invasive breast carcinomas. The results were then correlated with tumor grade, stage, estrogen receptor status, nodal status, and DNA ploidy. The expression of the proteins p53 and mdm2 was determined immunohistochemically using formalin-fixed, paraffin-embedded material. Screening for p53...

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PMID: 9260591
DOI: 10.1007/BF01240122

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