Article
E-cadherin is a tumour/invasion suppressor gene mutated in human lobular breast cancers.
The EMBO journal - 15 Dec 1995
Berx G, Cleton-Jansen A M, Nollet F, de Leeuw W J, van de Vijver M, Cornelisse C, van Roy F
Abstract excerpt
Compelling experimental evidence exists for a potent invasion suppressor role of the cell-cell adhesion molecule E-cadherin. In addition, a tumour suppressor effect has been suggested for E-cadherin. In human cancers, partial or complete loss of E-cadherin expression correlates with malignancy. T...
Topics
- Base Sequence
- Breast Neoplasms
- Cadherins
- Carcinoma, Ductal, Breast
- Carcinoma, Lobular
- Chromosomes, Human, Pair 16
- DNA Primers
- DNA, Neoplasm
- Female
- Genes, Tumor Suppressor
- Heterozygote
- Humans
- Immunohistochemistry
- Molecular Sequence Data
- Mutation
- Polymerase Chain Reaction
- Polymorphism, Single-Stranded Conformational