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Article

E-cadherin is a tumour/invasion suppressor gene mutated in human lobular breast cancers.

The EMBO journal - 15 Dec 1995

Berx G, Cleton-Jansen A M, Nollet F, de Leeuw W J, van de Vijver M, Cornelisse C, van Roy F

Abstract excerpt

Compelling experimental evidence exists for a potent invasion suppressor role of the cell-cell adhesion molecule E-cadherin. In addition, a tumour suppressor effect has been suggested for E-cadherin. In human cancers, partial or complete loss of E-cadherin expression correlates with malignancy. To investigate the molecular basis for this altered expression we developed a comprehensive PCR/SSCP mutation screen for...

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Identifiers

PMID: 8557030
DOI: 10.1002/j.1460-2075.1995.tb00301.x
PMCID: PMC394735

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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E-cadherin is a tumour/invasion suppressor gene mutated in human lobular breast cancers.PMID 8557030Read ↗

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Lobular breast cancer: molecular basis, mouse and cellular modelsSemantic proximity Read ↗

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Mutations of the human E-cadherin (CDH1) gene.Semantic proximity Read ↗

Multiple ways of silencing E-cadherin gene expression in lobular carcinoma of the breast.Semantic proximity Read ↗

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Mutations of the E-cadherin gene in human gynecologic cancers.Semantic proximity Read ↗

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E-Cadherin Mutational Landscape and Outcomes in Breast Invasive Lobular Carcinoma.Semantic proximity Read ↗

Low Incidence of Germline and Somatic Alterations in the E-Cadherin Gene in Lobular Breast CarcinomaSemantic proximity Read ↗

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