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Article

p53 expression and relationship with MDM2 amplification in breast carcinomas.

Annals of diagnostic pathology - 1 Apr 2016

Buyukpinarbasili Nur, Gucin Zuhal, Ersoy Yeliz Emine, İlbak Ayca, Kadioglu Huseyin, Muslumanoglu Mahmut

Abstract excerpt

Carcinoma of the breast, like other malignancies, is a genetic disease with multiple genetic events leading to the malignant phenotype. p53 mutations are the most common genetic events in human cancer. Inactivation of p53 can be a result of mutation in gene sequence. One of the main structures that regulate p53 stabilization is MDM2. It suppresses p53 transcriptional activation by recognizing transactivation...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 27040927
DOI: 10.1016/j.anndiagpath.2016.01.001

Genes

MDM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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