TP53 abnormalities and genetic instability in breast cancer.

doi:10.3109/02841869509094045

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Article

TP53 abnormalities and genetic instability in breast cancer.

Acta oncologica (Stockholm, Sweden) - 1 Jan 1995

Eyfjörd J E, Thorlacius S, Valgardsdottir R, Gretarsdottir S, Steinarsdottir M, Anamthawat-Jonsson K

Abstract excerpt

TP53 abnormalities in breast carcinomas and inherited TP53 changes in breast cancer patients and in Li-Fraumeni-like families were looked for. Tumours were screened for mutations in the TP53 gene by means of the PCR-CDGE method followed by PCR and direct sequencing. Allelic loss was determined by...

Topics

Alleles
Breast Neoplasms
DNA Mutational Analysis
Female
Gene Amplification
Genes, erbB-2
Genes, p53
Germ-Line Mutation
Humans
In Situ Hybridization, Fluorescence
Mutation
Tumor Cells, Cultured

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